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Page: Clinical Use
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Indications
Aciclovir is indicated for the treatment of HSV and VZV infections, including:
* Genital herpes simplex (treatment and prophylaxis)
* Herpes simplex labialis (cold sores)
* Herpes zoster (shingles)
* Acute chickenpox in immunocompromised patients
* Herpes simplex encephalitis
* Acute mucocutaneous HSV infections in immunocompromised patients
* Herpes simplex keratitis (ocular herpes)
* Herpes simplex blepharitis (not to be mistaken with ocular herpes)
It has been claimed that the evidence for the effectiveness of topically applied cream for recurrent labial outbreaks is weak. Likewise oral therapy for episodes is inappropriate for most non-immunocompromised patients, whilst there is evidence for oral prophylactic role in preventing recurrences.
Dosage forms
Aciclovir is commonly marketed as tablets (200 mg and 400 mg), topical cream (5%), intravenous injection (25 mg/mL) and ophthalmic ointment (3%). Cream preparations are used primarily for labial herpes simplex. The intravenous injection is used when high concentrations of aciclovir are required. The ophthalmic ointment preparation is only used for herpes simplex keratitis .
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Important notice:
The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other
qualified health provider with any questions you may have regarding a medical condition.
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