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Digoxin has potentially dangerous interaction with verapamil, amiodarone and erythromycin.
In overdose, the usual supportive measures are needed. If arrhythmias prove troublesome, or malignant hyperkalaemia occurs (inexorably rising potassium level due to paralysis of the cell membrane bound ATPase-dependent Na/K pumps), the specific antidote is antidigoxin (antibody fragments against digoxin, trade names of Digibind® and Digifab®). Toxicity can also be treated with higher than normal doses of potassium. Digoxin is not removed by hemo or peritoneal dialysis with enough effectiveness to treat toxicity.
Some physical properties of digoxin are water solubility of 64.8 mg/L at 25 °C and melting point at 249.3 °C.
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