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Page: Timeline
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* 1922 Banting, Best, Collip use bovine insulin extract in human
* 1923 Eli Lilly produces commercial quantities of much purer bovine insulin than Banting et al had used
* 1923 Hagedorn founds the Nordisk Insulinlaboratorium in Denmark -- forerunner of Novo Nordisk
* 1926 Nordisk receives a Danish charter to produce insulin as a non profit
* 1936 Canadians D.M. Scott, A.M. Fisher formulate a zinc insulin mixture and license it to Novo
* 1936 Hagedorn discovers that adding protamine to insulin prolongs the duration of action of insulin
* 1946 Nordisk formulates Isophane porcine insulin aka Neutral Protamine Hagedorn or NPH insulin
* 1946 Nordisk crystallizes a protamine and insulin mixture
* 1950 Nordisk markets NPH insulin
* 1953 Novo formulates Lente porcine and bovine insulins by adding zinc for longer lasting insulin
* 1955 Frederick Sanger determines the amino acid sequence of insulin
* 1969 Dorothy Crowfoot Hodgkin solves the crystal structure of insulin by x-ray crystallography
* 1973 Purified monocomponent (MC) insulin is introduced
* 1978 Genentech produces human insulin in Escheria coli bacteria using recombinant DNA techniques, licenses to Eli Lilly
* 1981 Novo Nordisk chemically and enzymatically converts bovine to human insulin
* 1982 Genentech human insulin (above) approved
* 1983 Eli Lilly produces recombinant human insulin, Humulin
* 1985 Axel Ullrich sequences a human cell membrane insulin receptor
* 1988 Novo Nordisk produces recombinant human insulin
* 1996 Lilly Humalog "lyspro" insulin analogue approved
* 2004 Aventis Lantus "glargine" insulin analogue approved for clinical use[citation needed]
* 2006 Novo Nordisk Levemir "detemir" insulin analogue approved for clinical use in the US.
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