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Page: Physiology
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Amblyopia is a developmental problem in the brain, not an organic problem in the eye (although organic problems can induce amblyopic symptoms which persist after the organic problem has resolved). The part of the brain corresponding to the visual system from the affected eye is not stimulated properly, and develops abnormally. This has been confirmed via direct brain examination. David H. Hubel and Torsten Wiesel won the Nobel Prize in Physiology or Medicine in 1981 for their work demonstrating the irreversible damage to ocular dominance columns produced in kittens by sufficient visual deprivation during the so-called "critical period".
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