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Page: Incidence
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The incidence of Down syndrome is estimated at 1 per 800 to 1 per 1000 births.[13] In 2006, the Center for Disease Control estimated the rate as 1 per 733 live births in the United States (5429 new cases per year). Approximately 95% of these are trisomy 21. Down syndrome occurs in all ethnic groups and among all economic classes.
Maternal age influences the risk of conceiving a baby with Down syndrome. At maternal age 20 to 24, the risk is 1/1490; at age 40 the risk is 1/60, and at age 49 the risk is 1/11.[12] Although the risk increases with maternal age, 80% of children with Down syndrome are born to women under the age of 35, reflecting the overall fertility of that age group. Other than maternal age, no other risk factors are known. There does not appear to be a paternal age effect.
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