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Page: Contraindications
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* Epilepsy and other conditions that lower the seizure threshold (alcohol withdrawal, active brain tumors, etc.)
* Concomitant treatment with MAO inhibitors. When switching medications it is important that there be a short period of about two weeks between the medications in order to reduce risk of complications that might lead to things such as a decrease in seizure threshold.
* Caution with the concomitant use of sympathomimetic drugs (e.g. ephedrine)
* Active liver damage (e.g. cirrhosis)
* Anorexia nervosa and bulimia which might lead the patient to have a decreased seizure threshold
* Severe kidney disease
* Severe hypertension
* Anxiety disorders (caution), agitated patients
* Pediatric patients (see below)
* Use considerable caution in treating patients where suicide may be a risk
* Psychosis, as bupropion therapy has a record of worsening and sometimes causing hallucinations, paranoia, and feelings of persecution.
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