Pathogenesis

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Colorectal cancer is a disease originating from the epithelial cells lining the gastrointestinal tract. Mutations in specific DNA sequences, among which are included the APC, K-Ras and p53 genes, lead to unrestricted cell division. Various causes for these mutations are inborn genetic aberrations, tobacco smoking, environmental, and possibly viral causes. The exact reason why (and whether) a diet high in fiber might prevent colorectal cancer remains uncertain. Chronic inflammation, as in inflammatory bowel disease, may predispose patients to malignancy.

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