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Page: Interactions
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Iron forms an insoluble complex with several other drugs, resulting in decreased absorption of both iron and the other drug. Examples include tetracycline, penicillamine, methyldopa, levodopa, bisphosphonates and quinolones. The same can occur with elements in food, such as calcium. Absorption of iron is better at a low pH (an acid environment), and resorption is decreased if there is a simultaneous intake of antacids, phosphates, etc.
Taken after a meal, there are less side effects but there is also less absorption because of interaction and pH alteration. Generally, an interval of 2-3h between the iron intake and that of other drugs seems advisable.
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