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Page: Haemophilia
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Haemophilia or hemophilia is the name of several hereditary genetic illnesses that impair the body's ability to control bleeding, an impairment known technically as bleeding diathesis. Genetic deficiencies and a rare autoimmune disorder may cause lowered plasma clotting factor activity so as to compromise blood-clotting; when a blood vessel is injured, a scab does not form and the vessel continues to bleed for an excessive period of time. The bleeding can be external, if the skin is broken by a scrape, cut or abrasion, or it can be internal, into muscles, joints or hollow organs. The result may be visible (e.g., skin bruises) or subtle (e.g., melena, hematuria, or bleeding in the brain). This is called the lack of clotting factors - Haemophilia A has a lack of the clotting Factor VIII, Haemophilia B has a lack of the clotting Factor IX, and Haemophilia C has a lack of the clotting Factor XI. Haemophilia A occurs in 90% of cases.
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