Blood Disorders

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Blood Disorders


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Anemia
Anaemia is a low red blood cell count. There can be many causes including iron deficiency or more serious disease.

Blood Disorders - Anemia...
Blood Disorders - Signs and Symptoms...
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Blood Disorders - Classification...
Blood Disorders - Specific Anemias...
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Blood Disorders - Anemia During Pregnancy...
Blood Disorders - Diet and Anemia...
Blood Disorders - Treatments for Anemia...


Edema
This article outlines the mechanisms of oedema and possible causes.

Blood Disorders - Edema...
Blood Disorders - Peripheral Oedema...
Blood Disorders - Organ-specific Oedema...
Blood Disorders - Edema in plants...
Blood Disorders - Edema in Fish...


Gland
This article gives an overview of some of the important glands in the body

Blood Disorders - Gland...
Blood Disorders - Types of Gland...
Blood Disorders - Formation...


Haemochromatosis
The gene that controls the amount of iron absorbed from food is called HFE. The HFE gene has two common mutations, C282Y and H63D. Inheriting just one of the C282Y mutations (heterozygous) makes a person a carrier who can pass this mutation onward. One mutation may lead to slightly excessive iron absorbtion but usually haemochromatosis does not develop. In the United States, most people with haemochromatosis have inherited two copies of C282Y — one from each parent — and are homozygous for the trait. Mutations of the HFE gene account for 90% of the cases. This gene is closely linked to the HLA-A3 locus. Homozygosity for the C282Y mutation is the most important one, although the heterozygosity C282Y/H63D mutations are also associated to disease (both conditions are sufficient to reach the diagnosis). Carriers of a single copy of either gene have a very slight risk of haemochromatosis when other factors contribute, but are otherwise healthy. Even if an individual has both copies of the abnormal gene the risk of actual clinical haemochromatosis is low (between 1—25%) due to incomplete penetrance. The variability in these estimates is probably due to different populations studied and how penetrance was defined. Other genes that cause haemochromatosis are the autosomal dominant SLC11A3/ferroportin 1 gene and TfR2 (transferrin receptor 2). They are much rarer than HFE-haemochromatosis. Recently, a classification has been developed (with chromosome locations): * Haemochromatosis type 1 (Mendelian Inheritance in Man (OMIM) 235200): "classical" HFE-haemochromatosis (6p21.3). * Haemochromatosis type 2 (Mendelian Inheritance in Man (OMIM) 602390): juvenile haemochromatosis : o Type 2A:(Mendelian Inheritance in Man (OMIM) 602390): mutations in hemojuvelin ("HJV", also known as HFE2) o Type 2B (Mendelian Inheritance in Man (OMIM) 606464): mutation in hepcidin antimicrobial peptide (HAMP) or HFE2B (19q13) * Haemochromatosis type 3 (Mendelian Inheritance in Man (OMIM) 604720): transferrin receptor-2 (TFR2 or HFE3, 7q22). * Haemochromatosis type 4 (Mendelian Inheritance in Man (OMIM) 604653): autosomal dominant haemochromatosis (all others are recessive), ferroportin (SLC11A3) gene mutation (2q32).

Blood Disorders - Haemochromatosis...
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Haemophilia
This inherited lifelong condition affects the blood clotting factors in some people. This article describes the condition, its effects, complications, treatment and inheritance.

Blood Disorders - Haemophilia...
Blood Disorders - History...
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Blood Disorders - Treatment...


Hodgkin's Lymphoma
This is a form of cancer involving the lymph glands;this article outilnes the symptoms ,investigations and treatment.

Blood Disorders - Hodgkin's Lymphoma...
Blood Disorders - Epidemiology...
Blood Disorders - Symptoms...
Blood Disorders - Diagnosis...
Blood Disorders - Pathology...
Blood Disorders - Types...
Blood Disorders - Staging...
Blood Disorders - Prognosis...
Blood Disorders - Treatment...


Iron Supplements
Iron supplements are used to treat iron deficiencies. This article profiles the various medications and how they should be used

Blood Disorders - Iron Supplements...
Blood Disorders - Indications...
Blood Disorders - Administration...
Blood Disorders - Side Effects...
Blood Disorders - Contraindications...
Blood Disorders - Interactions...
Blood Disorders - Precautions...
Blood Disorders - Follow-up...


Leukemia
Survival rates for leukaemia are continually improving thanks to modern therapies. This article looks at the different forms of leukaemia and how the disease is treated.

Blood Disorders - Leukemia...
Blood Disorders - Symptoms...
Blood Disorders - Four Major Types...
Blood Disorders - Causes and Risk Factors...
Blood Disorders - Treatment Options for Leukemia by Type...


Myelodysplastic Syndrome
This is a blood disorder caused by changes in the bone marrow. It mainly affects people over the age of 50. This article discusses the symptoms and management of the syndrome.

Blood Disorders - Myelodysplastic Syndrome...
Blood Disorders - Signs and Symptoms...
Blood Disorders - Diagnosis...
Blood Disorders - Pathophysiology...
Blood Disorders - Types and classification...
Blood Disorders - Diagnosis...
Blood Disorders - Epidemiology...
Blood Disorders - Therapy...
Blood Disorders - History...


Pernicious Anemia
This is one of the causes of vitamin B12 deficiency. Sufferers can become anaemic, dizzy and short of breath. This article provides an overview of the condition and how it should be managed.

Blood Disorders - Pernicious Anemia...
Blood Disorders - Pathophysiology...
Blood Disorders - Differential Diagnosis...
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